Dr. Daniel Spencer
Head of Development
Ludger's Medical Glycomics Programmes have been established to study changes in glycosylation in different body states. These include inflammation, cancers, diabetes and CVD.
This area of study originated in the work published in Nature by Parekh et al in 1985 entitled 'Association of Rheumatoid Arthritis and Primary Osteoarthritis with Changes in the Glycosylation Pattern of Total Serum IgG' : Nature 316, 452-457 (01 August 1985) and has led to a strong initiative to explore the relevance of glycomics in Precision Medicine.
The glycomics data generated from our studies is being used for the following:
The importance of glycomics to healthcare is summarised in a recent report endorsed by the US Academies which stated that "glycans are directly involved in the pathophysiology of every major disease" and that "additional knowledge from glycoscience will be needed to realize the goals of precision medicine and to take advantage of the substantial investments in human genome and proteome research and its impact on human health". The name GlySign refers to the distinctive and complex changes in the glycomics profiles or 'Glycan Signatures' of the body's glycoproteins that occur during progression of many chronic diseases including cancers and inflammatory conditions. GlySign aims to train skilled glycomics specialists and offers 6 PhD positions for EarlyStage Researchers (2 based at Ludger). Ludger is joined in the GlySign consortium by Genos and Leiden University Medical Center.
Colorectal cancer (CRC) is the second most common cancer in Europe and is one of the most curable cancers when detected in its early stages. However, the heterogeneous nature of CRC leads to highly variable disease progression and outcome as well as treatment response, resulting in an urgent need for personalized treatment and biomarkers. GlyCoCan will enhance our understanding on the structure-function relationship of glycosylation in CRC. The goal is to discover improved diagnostic and prognostic biomarkers and pave the way for novel therapeutic targets.
MODY affects 1-4% of the diabetes patient population and it is estimated that at least 90% MODY patients are misdiagnosed and therefore, often prescribed ineffective treatment. A clinical diagnostics 'MODY' assay has been developed to identify patients with the most common form of MODY, HNF1A-type. These patients have reduced plasma outer arm fucosylation which is caused by defects in the HNF1A gene. The MODY assay is a plate based biochemical assay which provides a faster and more affordable alternative to genetic testing.
This exciting project, named GlycanDx-MODY, will be led by Ludger Ltd and includes the following partners; Genos (Croatia) and OCDEM (Oxford University, UK). The goal is to develop a clear business and technology plan for this assay to facilitate its incorporation into a diagnostic pathway for MODY which will ultimately be adopted by healthcare providers at the primary care level.
Protozoan parasites and helminths are the cause of some of the most devastating diseases worldwide and a major effort is needed to be able to control or eliminate these diseases. Glycoconjugates are present on the surface of many parasites and they are frequently involved in their survival strategies by forming a protective barrier against host defences. GlycoPar has been set up to study parasite glycobiology in detail and translate this research into successful therapeutic strategies.
The aim of IBD-Biom is to discover new, more reliable clinical biomarkers for IBD to allow the early diagnosis of patients and to point to possible molecular targets for new, improved therapies for patients. To date, genome-wide association studies have identified around 100 IBD susceptibility loci but clinical application has been limited. In this programme, an IBD biomarker discovery and assay system (IBD-BDAS) will be developed and used for biological samples from 6000 well characterised IBD patients and controls with the aim of identifying possible biomarkers.
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Dr. Daniel Spencer
Head of Development