Ludger has an active R&D programme for development of new glycoanalysis methods with an emphasis on improving reliability, sensitivity, sample throughput and cost. These methods are designed for lifecycle and brand-to-brand comparability of glycoprotein therapeutics that have complex, variable and microheterogeneous glycosylation.
In addition to this, Ludger is now developing practical systems for longitudinal analysis of glycosylation patterns in body fluids such as blood, saliva and mucous to monitor inflammatory conditions.
To enable analysis of multiple samples using various orthogonal analytical techniques, Ludger has been developing its ‘LongBow’ glycomics system. This comprises an integrated set of glycoprofiling modules for semi-automated high throughput N- and O-glycoprofiling of complex biological samples with analysis on multiple analytical platforms, such as UHPLC and MS.
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How we can improve the safety and efficacy of drugs by understanding and influencing glycosylation
Identifying glycosylation features of diseases, leading to improved diagnostics and therapeutics