Sialic acid standards

Sialic Acid Standards

Sialic Acids (a family of derivatives of neuraminic acid) are usually found as terminal structures of both N-linked and O-linked glycans.

Being located at the terminal position of glycans, sialic acids are a likely point of contact for many glycoprotein interactions. They are also important for the stability and 3D conformation of glycoproteins and are involved in many biological interactions:

  • Sialyation of IgG reduces ADCC and increases anti-inflammatory activity
  • Sialic acids increase the serum half-life of glycoproteins by preventing uptake by the liver’s asialoglycoprotein receptor
  • NGNA(Neu5Gc), a glycan not found in humans, can illicit an immune response and lead to increased neutralization of biopharmaceuticals.
  • Cell line choice can greatly influence the type of neuraminic acids present on a biopharmaceutical, for example a large portion of the sialic acids on mouse IgG are often NGNA.
N-acetylneuraminic acid qualitative standard

N-acetylneuraminic acid qualitative standard

CM-NEU5,9AC2-01

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5-N-acetyl-9-O-acetyl neuraminic acid standard (Neu5,9Ac2).

Sialic acid reference panel

Sialic acid reference panel

CM-SRP-01

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CM-SRP-01 panel is a standalone product as well as a component in the LudgerTag DMB sialic acid release and labelling kit (LT-KDMB-A1). This kit and the panel can assist you in performing sialic acid analysis which is a regulatory requirement to monitor the level and types of sialic acids during all stages of biopharmaceutical realisation.

Sialidase testing panel (2-AB labelled)

Sialidase testing panel (2-AB labelled)

CAB-STP-NEUAC-01

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The Sialidase Testing Panel contains a mixture of α2-3, α2-6, and α2-8 sialylated oligosaccharides labelled with either 2-AB or procainamide. They were developed as a process control for sialidase digestions. Applied alongside the samples, it demonstratesshows that the enzymes have the expected specificity.

N-acetylneuraminic acid qualitative standard

N-acetylneuraminic acid qualitative standard

CM-NEU-AC-01

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N-acetylneuraminic acid (Neu5Ac or NANA) quantitative standard, 1 nmol

Sialidase testing panel (procainamide labelled)

Sialidase testing panel (procainamide labelled)

CPROC-STP-NEUAC-01

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The Sialidase Testing Panel contains a mixture of α2-3, α2-6, and α2-8 sialylated oligosaccharides labelled with either 2-AB or procainamide. They were developed as a process control for sialidase digestions. Applied alongside the samples, it demonstratesshows that the enzymes have the expected specificity.

N-acetylneuraminic acid qualitative standard

N-acetylneuraminic acid qualitative standard

CM-NEUAC-100

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N -acetylneuraminic acid (Neu5Ac or NANA) quantitative standard, 100 nmol

N-glycolyneuraminic acid quantitative standard

N-glycolyneuraminic acid quantitative standard

CM-NEU-GC-01

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N-acetylneuraminic acid (Neu5Ac or NANA) quantitative standard, 1 nmol

N-glycolyneuraminic acid quantitative standard

N-glycolyneuraminic acid quantitative standard

CM-NEUGC-100

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N -acetylneuraminic acid (Neu5Ac or NANA) quantitative standard, 100 nmols

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