O-Glycan Standards

O-Glycan Standards


The O-linked glycans are linear or biantennary and contain an initial GalNAc residue. O-Glycans are grouped into eight core structures, however, the most common O-glycans generally belong to core 1 and 2. These glycans are provided with a free reducing terminus (aldol), or are derivatized as a fluorescently labelled glycoside. The fluorescent labels that are commonly used are 2-AA and 2-AB.

O-glycans are present in biopharmaceuticals such as erythropoeitin (EPO), Etanercept (Enbrel) and human Factor VIII (FVIII).Core 1 and Core 2 O-glycans are also present in biopharmaceuticals such as erythropoeitin (EPO), Etanercept (Enbrel), humanFactor VIII(FVIII), Factor IX and insulin glargine.

The Ludger standards have a purity of >90% as assessed by HILIC-HPLC and can be used as internal references or system suitability standards for peak assignment during HPLC or UPLC analysis.

2AB labelled core 1 O- glycan, C1

CAB-C1-01

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Core 1 2-AB labeled glycan Galactose-ß-(1-3)-GalNAc

2AB labelled sialylated core 1 O glycan, C1S(3)1

CAB-C1S(3)1-01

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2-AB labelled sialylated core 1 O-glycan, C1S(3)1

2AB labelled sialylated core 1 O glycan, C1S(3)1

CAB-C1S(3)1-02

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2-AB labelled sialylated core 1 O-glycan, C1S(3)1

2AB labelled core 1 O- glycan, C1

CAB-C1S(3,6)2-01

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Disialylated core 1 O-glycan, C1S(3,6)2, 2-AB labeled

2AB labelled di-sialylated core 2 O glycan, C2S(3,3)2

CAB-C2S(3,3)2-01

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2-AB labeled disialylated core 2 glycan, C2S(3,3)2

2AB labelled di-sialylated core 2 O glycan, C2S(3,3)2

CAB-C2S(3,3)2-02

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2-AB labeled disialylated core 2 glycan, C2S(3,3)2

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