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Dr Louise Royle - Short Biography

Dr Louise Royal -  Head of Glycoprofiling, at Ludger


Dr Louise Royle - Head of Glycoprofiling

Louise joined Ludger in 2007 and is Head of Glycoprofiling. Louise has over nineteen years of experience in analysis of O-glycans, N-glycans and glycosphingolipid head groups using HPLC/UPLC, exoglycosidase sequencing, MALDI, LC-MS and MS/MS analysis. She spent eight years working with Prof. Pauline Rudd and Prof. Raymond Dwek at the Oxford Glycobiology Institute then a year in Ireland at NIBRT as head of the analytical group. Louise is particularly interested in making glycan analysis accessible, robust and high throughput in order to allow progression in the understanding of the role of glycans in health and disease. She is an author of over 100 peer-reviewed articles, over 70 of which are in the field of glycobiology, including biopharmaceuticals and biomarker discovery. She graduated in Biochemistry from Manchester University before working at the Medical Research Council Radiobiology Institute and then gaining a PhD in Chemistry from Durham University on radio-immunotherapy and imaging. She then spent 3 years at Reading University developing Capillary Electrophoresis methods for the analysis of foodstuffs before moving into the field of glycobiology.


Key Publications

1. Shahrokh Z, Royle L, Saldova R, Bones J, Abrahams JL, Artemenko NV, Flatman S, Davies M, Baycroft A, Sehgal S, Heartlein MW, Harvey DJ, Rudd PM. Erythropoietin Produced in a Human Cell Line (Dynepo) Has Significant Differences in Glycosylation Compared with Erythropoietins Produced in CHO Cell Lines. Mol Pharm. 2011, 8(1), 286-296. 

2. Royle L, Campbell MP, Radcliffe CM, White DM, Harvey DJ, Abrahams JL, Kim YG, Henry GW, Shadick NA, Weinblatt ME, Lee DM, Rudd PM, Dwek RA. HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software. Anal Biochem. 2008,376(1),1-12.

3. Royle L, Roos A, Harvey DJ, Wormald MR, van Gijlswijk-Janssen D, Redwan el-RM, Wilson IA, Daha MR, Dwek RA, Rudd PM. Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems. J. Biol. Chem (2003), 278, 20140-20153. 

4. Peracaula R, Royle L, Tabares G, Mallorqui-Fernandez G, Barrabes S, Harvey DJ, Dwek RA, Rudd PM, de Llorens R. Glycosylation of human pancreatic ribonuclease: differences between normal and tumour states. Glycobiol. (2003), 13, 227-244. 

5. Saldova R, Royle L, Radcliffe CM, Abd Hamid UM, Evans R, Arnold JN, Banks RE, Hutson R, Harvey DJ, Antrobus R, Petrescu SM, Dwek RA, Rudd PM. Ovarian Cancer is Associated with Changes in Glycosylation in Both Acute-Phase Proteins and IgG. Glycobiology. 2007 (17),1344-56. 

6. Campbell MP, Royle L, Radcliffe CM, Dwek RA, Rudd PM. GlycoBase and autoGU: tools for HPLC-based glycan analysis.Bioinformatics. Bioinformatics. 2008 May 1;24(9):1214-6.

Pubmed link: NOT+Murray+L%5BAuth%5D