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Dr Daniel Spencer - Short Biography

Dr Daniel Spencer - Head of Development at Ludger


Dr Daniel Spencer - Head of Development at Ludger

Daniel is Head of Development at Ludger. He leads a team of scientists in developing new analytical tools for glycan analysis. He has over twenty years of experience in the field of glycoanalysis having worked with tumour markers, antibodies to tumour targets and proteomics. He has extensive experience in HPLC, UHPLC and mass spectrometry techniques for glycan and glycopeptide analysis. The Development team have lead the way in quantitative analysis of glycans having developed a range of glycan and glycopeptide standards where quantities are assured using robust orthogonal techniques and it is with these standards that new, robust, easy to use high throughput glycan analysis techniques have been developed. Daniel has lead the research for 3 European Union FP7 grants, EuroGlycoarrays, HighGlycan and IBD-Biom, and will soon start the GlycoPar programme investigating parasite acquired human diseases. 


Key Publications

1. Differential response in downstream processing of CHO cells grown under mild hypothermic conditions., Tait AS, Tarrant RD, Velez-Suberbie ML, Spencer DI, Bracewell DG. Biotechnol Prog. 2013 May;29(3):688-96.

2. Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Mouquet H, Scharf L, Euler Z, Liu Y, Eden C, Scheid JF, Halper-Stromberg A, Gnanapragasam PN, Spencer DI, Seaman MS, Schuitemaker H, Feizi T, Nussenzweig MC, Bjorkman PJ. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3268-77.

3. Impact of aeration strategy on CHO cell performance during antibody production. Velez-Suberbie ML, Tarrant RD, Tait AS, Spencer DI, Bracewell DG. Biotechnol Prog. 2013 Jan-Feb;29(1):116-26.

4. Production and fragmentation of negative ions from neutral N-linked carbohydrates ionized by matrix-assisted laser desorption/ionization. Domann P, Spencer DI, Harvey DJ. Rapid Commun Mass Spectrom. 2012 Feb 29;26(4):469-79.

5. Glycoforms obtained by expression in Pichia pastoris improve cancer targeting potential of a recombinant antibody-enzyme fusion protein. Medzihradszky KF, Spencer DI, Sharma SK, Bhatia J, Pedley RB, Read DA, Begent RH, Chester KA. Glycobiology. 2004 Jan;14(1):27-37